【广东会GDH基因检测】飞行质谱基因检测发现ADRA2A有突变，严重吗？

基因检测的序列名称：

ADRA2A

人体基因序列变化与疾病表征数据库中的基因代码：

150

人体基因序列数据库中国际交流名称全称

adrenoceptor alpha 2A

中国数据库中基因全称：肾上腺素受体2A基因检测报告英文版基因简介

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

基因突变所影响的基因信息

Alpha-2-肾上腺素受体是G蛋白偶联受体超家族的成员。它们包括3个高度同源的亚型：alpha2A，alpha2B和alpha2C。这些受体在调节交感神经和中枢神经系统中肾上腺素能神经元的神经递质释放中起关键作用。小鼠研究表明，正常的突触前控制心脏中交感神经和中枢去甲肾上腺素能神经元的递质释放需要α2A和α2C亚型。alpha2A亚型在高刺激频率下抑制了递质的释放，而alpha2C亚型在较低的神经活动水平下调节了神经传递。该基因编码alpha2A亚型，并且在其编码序列或非翻译序列中均不含内含子。[由Reು୔

国际国内该碱基因序列的其他英语文字母简称：

ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32

基因解码对该基因序列在细胞核中的染色体所给予的编号：

该基因序列位于人类第10号染色体上。

基因解码对基因序列的正确定位

该基因序列在GRCh37版本中的起始位置坐标为：112836790；结束位置坐标为：112840665。该基因序列在GRCh38版本中的起始位置坐标为：111077032；结束位置坐标为：111080907。正确的基因信息定位是基因检测和对检测结果进行正确解读的关键。

广东会GDH基因解码对该基因的功能分类：国际版

G-protein coupled receptors/GPCRs excl olfactory receptors

基因解码对该基因的功能分类：中文版

G 蛋白偶联受体/GPCR 不包括嗅觉受体

结构与功能基因解码所揭示的该基因在细胞内发挥作用的场所（国际版）：

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结构与功能基因解码所揭示的该基因发挥作用的细胞内位置（中文版）：

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该基因序列变化后增加的疾病风险（国际版）：

Panic Disorder; Fibrosis; Heart Diseases; Hypotension; Cardiomegaly; Mood Disorders; Mental Depression; Alcoholic Intoxication, Chronic; Hypertensive disease; Depressive disorder; Epilepsy; Schizophrenia

如果该基因突变后，风险可能增加的疾病类型（中文版）：

恐慌症;纤维化；心脏疾病;低血压;心脏肥大；情绪障碍；精神抑郁症；酒精中毒慢性；高血压病；抑郁症；癫痫;精神分裂症

GWAS基因检测所建立的与该基因的疾病关联（国际版）：

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GWAS基因检测所解码的该基因突变会增加风险的疾病种类（中文版）：

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以该基因做靶点的药物（国际版）：

Bethanidine (Thioesterase binding);Ziprasidone (Thioesterase binding);Cabergoline (Thioesterase binding);Ropinirole (Thioesterase binding);Dihydroergotamine (Thioesterase binding);Amitriptyline (Thioesterase binding);Olanzapine (Thioesterase binding);Clozapine (Thioesterase binding);Norepinephrine (Thioesterase binding);Mirtazapine (Thioesterase binding);Phenylpropanolamine (Thioesterase binding);Loxapine (Thioesterase binding);Pramipexole (Thioesterase binding);Dipivefrin (Thioesterase binding);Prazosin (Thioesterase binding);Chlorpromazine (Thioesterase binding);Brimonidine (Thioesterase binding);Nortriptyline (Thioesterase binding);Amoxapine (Thioesterase binding);Amoxapine (Thioesterase binding);Clonidine (Thioesterase binding);Lisuride (Thioesterase binding);Guanabenz (Thioesterase binding);Dexmedetomidine (Thioesterase binding);Trazodone (Thioesterase binding);Epinephrine (Thioesterase binding);Phentolamine (Thioesterase binding);Ergotamine (Thioesterase binding);Tizanidine (Thioesterase binding);Apomorphine (Thioesterase binding);Trimipramine (Thioesterase binding);Risperidone (Thioesterase binding);Epinastine (Thioesterase binding);Tolazoline (Thioesterase binding);Fenoldopam (Thioesterase binding);Pseudoephedrine (Thioesterase binding);Benzphetamine (Thioesterase binding);Phenoxybenzamine (Thioesterase binding);Maprotiline (Thioesterase binding);Oxymetazoline (Thioesterase binding);Apraclonidine (Thioesterase binding);Methyldopa (Thioesterase binding);Guanfacine (Thioesterase binding);Ergoloid mesylate (Thioesterase binding);Carvedilol (Thioesterase binding);Doxepin (Thioesterase binding);Nefazodone (Thioesterase binding);Desipramine (Thioesterase binding);Pergolide (Thioesterase binding);Bromocriptine (Thioesterase binding);Quetiapine (Thioesterase binding);Aripiprazole (Thioesterase binding);Paliperidone (Thioesterase binding);Ephedra (Thioesterase binding);Yohimbine (Thioesterase binding);Methotrimeprazine (Thioesterase binding);4-Methoxyamphetamine (Thioesterase binding);Methamphetamine (Thioesterase binding);Propericiazine (Thioesterase binding);Zuclopenthixol (Thioesterase binding);Dronedarone (Thioesterase binding);Lofexidine (Thioesterase binding);Epicept NP-1 (Thioesterase binding);Mianserin (Thioesterase binding);Asenapine (Thioesterase binding);Droxidopa (Thioesterase binding);Flupirtine (Thioesterase binding);Esmirtazapine (Thioesterase binding);Xylometazoline (Thioesterase binding);Naphazoline (Thioesterase binding);Lurasidone (Thioesterase binding);Cirazoline (Thioesterase binding)

针对该基因所产生的突变，可能有正确效果的药物（中文版）：

倍他尼定（硫酯酶结合）；齐拉西酮（硫酯酶结合）；卡麦角林（硫酯酶结合）；罗匹尼罗（硫酯酶结合）；二氢麦角胺（硫酯酶结合）；阿米替林（硫酯酶结合）；奥氮平（硫酯酶结合）；氯氮平（硫酯酶结合）；去甲肾上腺素（硫酯酶结合);米氮平(硫酯酶结合);苯丙醇胺(硫酯酶结合);洛沙平(硫酯酶结合);普拉克索(硫酯酶结合);地匹夫林(硫酯酶结合);哌唑嗪(硫酯酶结合);氯丙嗪(硫酯酶结合);溴莫尼定(硫酯酶结合) )；去甲替林（硫酯酶结合）；阿莫沙平（硫酯酶结合）；阿莫沙平（硫酯酶结合）；可乐定（硫酯酶结合）；麦角乙脲（硫酯酶结合）；瓜那苯（硫酯酶结合）；右美托咪定（硫酯酶结合）；曲唑酮（硫酯酶结合）；肾上腺素（硫酯酶结合）;酚妥拉明（硫酯酶结合）;麦角胺（硫酯酶结合）;替扎尼定（硫酯酶结合）;阿朴吗啡（硫酯酶结合）;曲米帕明（硫酯酶结合）;利培酮（硫酯酶结合）;依匹斯汀（硫酯酶结合）;托拉唑啉（硫酯酶结合）；非诺多泮（硫酯酶结合）；伪麻黄碱（硫酯酶结合）；苯丙胺（硫酯酶结合）；苯氧苯甲胺（硫酯酶结合）；马普替林（硫酯酶结合）；羟甲唑啉（硫酯酶结合）；安普乐定（硫酯酶结合）；甲基多巴（硫酯酶结合） )；胍法辛（硫酯酶结合）；麦角环素甲磺酸盐（硫酯酶结合）；卡维地洛（硫酯酶结合）；多虑平（硫酯酶结合）；奈法唑酮（硫酯酶结合）；地昔帕明（硫酯酶结合）；培高利特（硫酯酶结合）；溴隐亭（硫酯酶结合） ;喹硫平（硫酯酶结合）；阿立哌唑（硫酯酶结合）；帕利哌酮（硫酯酶结合）；麻黄（硫酯酶结合）；育亨宾（硫酯酶结合）；甲氧美拉嗪（硫酯酶结合）；4-甲氧苯丙胺（硫酯酶结合）；甲基苯丙胺（硫酯酶结合） ;丙哌嗪（硫酯酶结合）；珠氯噻醇（硫酯酶结合）；决奈达隆（硫酯酶结合）；洛非西定（硫酯酶结合）；Epicept NP-1（硫酯酶结合）；米安色林（硫酯酶结合）；阿塞那平（硫酯酶结合）；屈昔多巴（硫酯酶结合） )；氟吡汀（硫酯酶结合）；艾司米氮平（硫酯酶结合）；赛洛唑啉（硫酯酶结合）；萘甲唑啉（硫酯酶结合）；鲁拉西酮（硫酯酶结合）；西拉唑啉（硫酯酶结合）

(责任编辑：广东会GDH基因)